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Explore how α-ketoglutarate, a central TCA cycle intermediate, emerges as a powerful longevity compound through epigenetic regulation, hormetic stress responses, and caloric restriction mimicry. Discover its mechanisms from molecular to organismal levels.
Comprehensive analysis of different NMN and NAD+ supplementation methods including oral, sublingual, IV, and emerging delivery systems. Learn bioavailability, effectiveness, and practical considerations for each approach.
Discover how metformin—originally derived from French lilac—accidentally became one of the most powerful anti-aging drugs ever studied. Learn the fascinating molecular mechanisms that make this humble diabetes medication a cellular fountain of youth.
Compare the molecular mechanisms and longevity benefits of intermittent fasting versus caloric restriction. Discover how these dietary interventions activate mTOR, autophagy, and sirtuins differently to extend healthspan and potentially slow aging.
Forget your birthday—discover how epigenetic clocks reveal your true biological age through DNA methylation patterns. Learn about the revolutionary Horvath clock and what it means for anti-aging research.
Discover NAD+ (Nicotinamide adenine dinucleotide), the essential coenzyme that powers cellular energy production, DNA repair, and anti-aging processes. Learn how NAD+ decline drives aging and how to boost NAD+ levels naturally.
Discover NMN (Nicotinamide mononucleotide), the promising anti-aging supplement that boosts NAD+ levels. Learn about its mechanisms, benefits, dosage, and the latest research from Harvard's David Sinclair.
Discover David A. Sinclair, the renowned Harvard geneticist and longevity researcher whose groundbreaking work on sirtuins, NAD+, and the Information Theory of Aging is transforming our understanding of how we age and how we might extend human healthspan.
Discover David Sinclair's revolutionary Information Theory of Aging in 'Lifespan: Why We Age—and Why We Don't Have To'. Learn how sirtuins, NAD+, and lifestyle interventions may extend human healthspan and potentially reverse aging.
Metformin, well-known as an antidiabetic medication, research indicates, may also have anti-aging effects!
Discover how exercise combats aging at the cellular level through AMPK activation, mitochondrial biogenesis, senescent cell clearance, and longevity pathway optimization. Learn the molecular science behind exercise's anti-aging effects.